High purity pravastatin sodium CAS NO.81131-70-6

Name: High purity pravastatin sodium
SKU: 81131-70-6
Availability: InStock

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Basic information

Product Name:	Pravastatin sodium
Synonyms:	1-naphthaleneheptanoicacid,1,2,6,7,8,8a-hexahydro-2-methyl-8-(2-methyl-1-oxob;2-alpha,6-alpha,8-beta(r),8a-alpha))-;cs-514;epastatinsodium;lipostat;sq31000;utoxy)-beta,delta,6-trihydroxy-,monosodiumsalt,(1s-(1-alpha(beta-s*,delta-s;KOPOSTAT
CAS:	81131-70-6
MF:	C23H36NaO7
MW:	447.52
Product Categories:	Active Pharmaceutical Ingredients;Antihyperlipoproteinemic;Various Metabolites and Impurities;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;HMG-CoA reductase;Inhibitor;PRAVACHOL
Mol File:	81131-70-6.mol

Chemical Properties

Usage And Synthesis

Chemical Properties	White Crystalline Powder
Usage	A competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin
	antihyperlipidemic, HMGCoA reductase inhibitor
	Pravastatin sodium is the salt of pravastatin, a ring-opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of microorganisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a β-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoAreductase inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges.
	An HMGCR inhibitor which blocks cholesterol synthesis
Biological Activity	Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (K i ~ 1 nM) and displays cardioprotective properties.